Complement dysregulation in the central nervous system during development and disease
The complement cascade is an important arm of the immune system that plays a key role in
protecting the central nervous system (CNS) from infection. Recently, it has also become …
protecting the central nervous system (CNS) from infection. Recently, it has also become …
Complement system in brain architecture and neurodevelopmental disorders
J Magdalon, F Mansur, AL Teles e Silva… - Frontiers in …, 2020 - frontiersin.org
Current evidence indicates that certain immune molecules such as components of the
complement system are directly involved in neurobiological processes related to brain …
complement system are directly involved in neurobiological processes related to brain …
Complement: the emerging architect of the developing brain
Complement activation products have long been associated with roles in the innate immune
system, linking the humoral and cellular responses. However, among their recently …
system, linking the humoral and cellular responses. However, among their recently …
Serum complement proteins rather than inflammatory factors is effective in predicting psychosis in individuals at clinical high risk
Immunological/inflammatory factors are implicated in the development of psychosis.
Complement is a key driver of inflammation; however, it remains unknown which factor is …
Complement is a key driver of inflammation; however, it remains unknown which factor is …
Aberrant complement system activation in neurological disorders
K Ziabska, M Ziemka-Nalecz, P Pawelec… - International Journal of …, 2021 - mdpi.com
The complement system is an assembly of proteins that collectively participate in the
functions of the healthy and diseased brain. The complement system plays an important role …
functions of the healthy and diseased brain. The complement system plays an important role …
Peripheral complement is increased in schizophrenia and inversely related to cortical thickness
Background There is growing evidence for complement system involvement in the
pathophysiology of schizophrenia, although the extent and magnitude of complement factor …
pathophysiology of schizophrenia, although the extent and magnitude of complement factor …
Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure
Recent research has highlighted the role of complement genes in shaping the
microstructure of the brain during early development, and in contributing to common allele …
microstructure of the brain during early development, and in contributing to common allele …
Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress
The complement cascade is a major component of the immune defence against infection,
and there is increasing evidence for a role of dysregulated complement in major psychiatric …
and there is increasing evidence for a role of dysregulated complement in major psychiatric …
Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder
Deficits in brain morphology are one of the most widely replicated neuropathological
features in schizophrenia-spectrum disorder (SSD), although their biological underpinnings …
features in schizophrenia-spectrum disorder (SSD), although their biological underpinnings …
Increased cerebrospinal fluid complement C5 levels in major depressive disorder and schizophrenia
T Ishii, K Hattori, T Miyakawa, K Watanabe… - Biochemical and …, 2018 - Elsevier
Inflammation has been implicated in a variety of psychiatric disorders. We aimed to
determine whether levels of complement C5 protein in the cerebrospinal fluid (CSF), which …
determine whether levels of complement C5 protein in the cerebrospinal fluid (CSF), which …