Sex bias in lymphocytes: Implications for autoimmune diseases

KC Dodd, M Menon - Frontiers in Immunology, 2022 - frontiersin.org
Autoimmune diseases are characterized by a significant sex dimorphism, with women
showing increased susceptibility to disease. This is, at least in part, due to sex-dependent …

The roles of sex hormones in the course of atopic dermatitis

N Kanda, T Hoashi, H Saeki - International journal of molecular sciences, 2019 - mdpi.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by T helper 2 cell
(Th2)-shifted abnormal immunity, skin barrier impairment, and pruritus. The prevalence of …

T helper cell immunity in pregnancy and influence on autoimmune disease progression

JJ Graham, MS Longhi, MA Heneghan - Journal of autoimmunity, 2021 - Elsevier
Pregnancy presents the maternal immune system with a unique immunological challenge
since it has to defend against pathogens while tolerating paternal allo-antigens expressed …

The adaptive immune system in multiple sclerosis: an estrogen-mediated point of view

A Maglione, S Rolla, SFD Mercanti, S Cutrupi… - Cells, 2019 - mdpi.com
Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease that leads
to demyelination and neurodegeneration. The third trimester of pregnancy, which is …

LncRNA‐miRNA network analysis across the Th17 cell line reveals biomarker potency of lncRNA NEAT1 and KCNQ1OT1 in multiple sclerosis

E Karimi, H Azari, A Tahmasebi… - Journal of Cellular …, 2022 - Wiley Online Library
Differentiation of CD4+ T cells into Th17 cells is an important factor in the onset and
progression of multiple sclerosis (MS) and Th17/Treg imbalance. Little is known about the …

Multiple sclerosis and pregnancy: Pathogenesis, influencing factors, and treatment options

Y Wang, J Wang, J Feng - Autoimmunity Reviews, 2023 - Elsevier
Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central
nervous system, characterized by inflammatory demyelination. It is primarily found in women …

The role of sex hormones in women with multiple sclerosis: From puberty to assisted reproductive techniques

M Sparaco, S Bonavita - Frontiers in Neuroendocrinology, 2021 - Elsevier
Abstract Background Multiple Sclerosis is a multifactorial chronic autoimmune disease,
affecting predominantly females in the fertile age. Sex hormones changes during a woman's …

The emerging role of lncRNAs in multiple sclerosis

S Ghaderian, N Shomali, S Behravesh… - Journal of …, 2020 - Elsevier
Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the
central nervous system (CNS) with various clinical manifestations. The characteristic of MS …

[HTML][HTML] Conceiving complexity: Biological mechanisms underpinning the lasting effect of pregnancy on multiple sclerosis outcomes

MP Campagna, J Lechner-Scott, VE Maltby, RA Lea… - Autoimmunity …, 2023 - Elsevier
Multiple sclerosis (MS) is an autoimmune, demyelinating disease with the highest incidence
in women of childbearing age. The effect of pregnancy on disease activity and progression …

Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis

MP Campagna, A Xavier, J Stankovich, VE Maltby… - Clinical …, 2023 - Springer
Background Pregnancy in women with multiple sclerosis (wwMS) is associated with a
reduction of long-term disability progression. The mechanism that drives this effect is …