[HTML][HTML] Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development

BN Kanoi, H Nagaoka, M Morita, T Tsuboi… - Parasitology …, 2021 - Elsevier
Vaccines against infectious diseases have had great successes in the history of public
health. Major breakthroughs have occurred in the development of vaccine-based …

Targeting the Plasmodium falciparum proteome and organelles for potential antimalarial drug candidates

J Abugri, J Ayariga, SS Sunwiale, CA Wezena… - Heliyon, 2022 - cell.com
There is an unmet need to unearth alternative treatment options for malaria, wherein this
quest is more pressing in recent times due to high morbidity and mortality data arising mostly …

Glycosylphosphatidylinositol-anchored micronemal antigen (GAMA) interacts with the band 3 receptor to promote erythrocyte invasion by malaria parasites

J Lu, R Chu, Y Yin, H Yu, Q Xu, B Yang, Y Sun… - Journal of Biological …, 2022 - ASBMB
Glycosylphosphatidylinositol-anchored micronemal antigen (GAMA) is an erythrocyte
binding protein known to be involved in malarial parasite invasion. Although anti-GAMA …

Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population

BN Kanoi, H Nagaoka, MT White, M Morita… - Frontiers in …, 2020 - frontiersin.org
Clinical immunity to malaria develops after repeated exposure to Plasmodium falciparum
parasites. Broadly reactive antibodies against parasite antigens expressed on the surface of …

[HTML][HTML] Molecular docking and dynamics studies on plasmepsin V of malarial parasite Plasmodium vivax

M Sivaramakrishnan, K Kandaswamy… - Informatics in Medicine …, 2020 - Elsevier
Malaria is a fatal disease caused by plasmodium parasites and is transmitted through
female anopheles mosquitoes. These parasites dwell on human erythrocytes for most of …

Contriving a novel multi-epitope subunit vaccine from Plasmodium falciparum vaccine candidates against malaria

CO Mamudu, FN Iheagwam, EO Okafor… - Journal of Applied …, 2024 - japsonline.com
In this study, immunoinformatics strategies were used to design a subunit vaccine against
malaria from immunogenic regions of three Plasmodium falciparum surface antigens; liver …

Plasmodium falciparum serology: A comparison of two protein production methods for analysis of antibody responses by protein microarray

T Oulton, J Obiero, I Rodriguez, I Ssewanyana… - Plos one, 2022 - journals.plos.org
The evaluation of protein antigens as putative serologic biomarkers of infection has
increasingly shifted to high-throughput, multiplex approaches such as the protein …

Two 20-Residue-Long Peptides Derived from Plasmodium vivax Merozoite Surface Protein 10 EGF-Like Domains Are Involved in Binding to Human Reticulocytes

LA Ricaurte-Contreras, A Lovera… - International journal of …, 2021 - mdpi.com
Plasmodium parasites' invasion of their target cells is a complex, multi-step process
involving many protein-protein interactions. Little is known about how complex the …

GATS tag system is compatible with biotin labelling methods for protein analysis

K Yamada, F Soga, S Tokunaga, H Nagaoka… - Scientific Reports, 2023 - nature.com
Polypeptide tags and biotin labelling technologies are widely used for protein analyses in
biochemistry and cell biology. However, many peptide tag epitopes contain lysine residues …

Plasmodium falciparum metacaspase-2 capture its natural substrate in a non-canonical way

Vandana, R Pandey, E Srinivasan… - The Journal of …, 2021 - academic.oup.com
Programmed cell death (PCD) is a multi-step process initiated by a set of proteases, which
interacts and cleaves diverse proteins, thus modulating their biochemical and cellular …