The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

Stiffness in the tissue microenvironment changes in most diseases and immunological
conditions, but its direct influence on the immune system is poorly understood. Here, we …

T lymphocytes encounter complex mechanical cues during an immune response. The
mechanosensitive ion channel, Piezo1, drives inflammatory responses to bacterial …

Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in
all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel …

The tumor microenvironment (TME) is a complex macromolecular network filled with a series
of stromal cells. It plays an important role in tumorigenesis, development, immune escape …

Chimeric antigen receptor (CAR) T‐cell transfer is a novel paradigm of adoptive T‐cell
immunotherapy. When coming into contact with a target cancer cell, CAR T‐cell forms a …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

Tissue-resident CD8+ T cells (TRM) continuously scan peptide-MHC (pMHC) complexes in
their organ of residence to intercept microbial invaders. Recent data showed that TRM …

Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and
infected cells, which makes them unique 'off-the-shelf'candidates for a new generation of …