Virus-like particles: Revolutionary platforms for developing vaccines against emerging infectious diseases
Virus-like particles (VLPs) are nanostructures that possess diverse applications in
therapeutics, immunization, and diagnostics. With the recent advancements in biomedical …
therapeutics, immunization, and diagnostics. With the recent advancements in biomedical …
Advancements in prophylactic and therapeutic nanovaccines
Vaccines activate suitable immune responses to fight against diseases but can possess
limitations such as compromised efficacy and immunogenic responses, poor stability, and …
limitations such as compromised efficacy and immunogenic responses, poor stability, and …
Engineering self-assembling protein nanoparticles for therapeutic delivery
A Olshefsky, C Richardson, SH Pun… - Bioconjugate …, 2022 - ACS Publications
Despite remarkable advances over the past several decades, many therapeutic
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …
Protein‐based Nanoparticles: from Drug Delivery to Imaging, Nanocatalysis and Protein Therapy
J Kaltbeitzel, PR Wich - Angewandte Chemie International …, 2023 - Wiley Online Library
Proteins and enzymes are versatile biomaterials for a wide range of medical applications
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
due to their high specificity for receptors and substrates, high degradability, low toxicity, and …
Structural basis for peroxidase encapsulation inside the encapsulin from the Gram-negative pathogen Klebsiella pneumoniae
Encapsulins are self-assembling protein nanocompartments capable of selectively
encapsulating dedicated cargo proteins, including enzymes involved in iron storage, sulfur …
encapsulating dedicated cargo proteins, including enzymes involved in iron storage, sulfur …
Advances in encapsulin nanocompartment biology and engineering
JA Jones, TW Giessen - Biotechnology and bioengineering, 2021 - Wiley Online Library
Compartmentalization is an essential feature of all cells. It allows cells to segregate and
coordinate physiological functions in a controlled and ordered manner. Different …
coordinate physiological functions in a controlled and ordered manner. Different …
Encapsulin cargo loading: progress and potential
Encapsulins are a recently discovered class of prokaryotic self-assembling icosahedral
protein nanocompartments measuring between 24 and 42 nm in diameter, capable of …
protein nanocompartments measuring between 24 and 42 nm in diameter, capable of …
[HTML][HTML] Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system
A Van de Steen, R Khalife, N Colant, HM Khan… - Synthetic and Systems …, 2021 - Elsevier
Abstract The development of Drug Delivery Systems (DDS) has led to increasingly efficient
therapies for the treatment and detection of various diseases. DDS use a range of nanoscale …
therapies for the treatment and detection of various diseases. DDS use a range of nanoscale …
Encapsulins—Bacterial protein nanocompartments: Structure, properties, and application
AN Gabashvili, NS Chmelyuk, MV Efremova… - Biomolecules, 2020 - mdpi.com
Recently, a new class of prokaryotic compartments, collectively called encapsulins or protein
nanocompartments, has been discovered. The shell proteins of these structures self …
nanocompartments, has been discovered. The shell proteins of these structures self …
Structure and heterogeneity of a highly cargo-loaded encapsulin shell
Encapsulins are self-assembling protein nanocompartments able to selectively encapsulate
dedicated cargo enzymes. Encapsulins are widespread across bacterial and archaeal phyla …
dedicated cargo enzymes. Encapsulins are widespread across bacterial and archaeal phyla …