Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for
tissue homeostasis or to restore biological balance under stress. Over the decades, various …

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …

Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Molecular pathways of programmed cell death (PCD) are activated in various
neurodegenerative disorders including Parkinson's disease, amyotrophic lateral sclerosis …

In the human brain and spinal cord, neurons degenerate after acute insults (eg, stroke,
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …

Bcl-2-family proteins are central regulators of cell life and death. At least three major classes
of Bcl-2-family proteins have been delineated, including proapoptotic proteins that contain …

Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

The process of neuronal degeneration in motor neurone disease is complex. Several
genetic alterations may be involved in motor neurone injury in familial amyotrophic lateral …

Cervical myelopathy is the most serious complication of cervical spondylosis and is the most
common acquired cause of spinal cord dysfunction. This disorder was originally described …