Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

R Yan, R Jiang, L Hu, Y Deng, J Wen… - International journal of …, 2022 - nature.com
Medication-related osteonecrosis of the jaw (MRONJ) is primarily associated with
administering antiresorptive or antiangiogenic drugs. Despite significant research on …

Medication‐related osteonecrosis of the jaw‐like lesions in rodents: a comprehensive systematic review and meta‐analysis

S Kuroshima, M Sasaki, H Murata, T Sawase - Gerodontology, 2019 - Wiley Online Library
Objective The aim of this comprehensive systematic review and meta‐analysis was to
investigate the pathology and pathogenesis of medication‐related osteonecrosis of the jaw …

Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model

K Ogata, W Katagiri, M Osugi, T Kawai, Y Sugimura… - Bone, 2015 - Elsevier
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is defined as an exposed
necrotic bone in the oral cavity that does not heal after appropriate intervention for> 8 weeks …

Endothelial Progenitor Cells inhibit jaw osteonecrosis in a rat model: A major adverse effect of bisphosphonate therapy

T Tamari, R Elimelech, G Cohen, T Cohen, O Doppelt… - Scientific reports, 2019 - nature.com
Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of
antiresorptive and antiangiogenic therapies. MRONJ is identified by chronic wounds in the …

The risk of osteonecrosis on alveolar healing after tooth extraction and systemic administration of antiresorptive drugs in rodents: a systematic review

VL do Nascimento Poubel, CAB Silva… - Journal of Cranio …, 2018 - Elsevier
Purpose There is much concern about the increasing number of patients with medication-
related osteonecrosis of the jaw (MRONJ), and many studies have been published in an …

Effects of different doses of ionizing radiation on alveolar bone repair in post-extraction tooth socket: an experimental study in rats

JS Borges, IS Paula, NT de Araújo Reis… - Clinical Oral …, 2023 - Springer
Objective This study aimed to evaluate the dose–response effects of ionizing radiation (IR)
on alveolar bone repair and bone strength after tooth extraction. Materials and methods A …

Doses effects of zoledronic acid on mineral apatite and collagen quality of newly-formed bone in the rat's calvaria defect

C Olejnik, G Falgayrac, A During, B Cortet, G Penel - Bone, 2016 - Elsevier
Due to their inhibitory effects on resorption, bisphosphonates are widely used in the
treatment of diseases associated to an extensive bone loss. Yet, little is known about …

The effects of sodium alendronate on socket healing after tooth extraction: a systematic review of animal studies

NGM Chavarry, PVB Abreu, EJ Feres-Filho… - Brazilian Oral …, 2024 - SciELO Brasil
The aim of this systematic review was to answer the following question:“Does alendronate, a
nitrogen-containing bisphosphonate, improve or impair alveolar socket healing after tooth …

Bis-enoxacin inhibits bone resorption and orthodontic tooth movement

EJ Toro, J Zuo, A Guiterrez… - Journal of Dental …, 2013 - journals.sagepub.com
Enoxacin inhibits binding between the B-subunit of vacuolar H+-ATPase (V-ATPase) and
microfilaments, and also between osteoclast formation and bone resorption in vitro. We …

Alendronate improves bone density and type I collagen accumulation but increases the amount of pentosidine in the healing dental alveolus of ovariectomized rabbits

NGM Chavarry, D Perrone, MLF Farias, BC Dos Santos… - Bone, 2019 - Elsevier
Background It has been shown that the oral aminobisphosphonate sodium alendronate
(ALN) therapy reduces the risk of main fractures in osteoporotic women, but its effect on the …