Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …

Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …

Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in
cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant …

Few physiological parameters are more tightly and acutely regulated in humans than blood
glucose concentration. The major cellular mechanism that diminishes blood glucose when …

The signalling pathways utilised by insulin receptor (IR) and IGF receptor to transduce their
diverse effects on cellular metabolism, growth and survival are well established in broad …

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

In the past decade, there has been a resurgence of interest in elucidating how metabolism is
altered in cancer cells and how such dependencies can be targeted for therapeutic gain. At …

GLUT4 is an insulin-regulated glucose transporter that is responsible for insulin-regulated
glucose uptake into fat and muscle cells. In the absence of insulin, GLUT4 is mainly found in …

Phosphoinositide signaling lipids (PIPs) are key regulators of membrane identity and
trafficking. Of these, PI (3, 5) P2 is one of the least well-understood, despite key roles in …