Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Introduction: Our previous scientometric review of regenerative medicine provides a
snapshot of the fast-growing field up to the end of 2011. The new review identifies emerging …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Immune system defects are at the center of aging and a range of diseases. Here, we show
that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell …

Recent progresses in the field of Induced Pluripotent Stem Cells (iPSCs) have opened up
many gateways for the research in therapeutics. iPSCs are the cells which are …

Cellular reprogramming technology has created new opportunities in understanding human
disease, drug discovery, and regenerative medicine. While a combinatorial code was …

Stem cell therapy holds the promise to treat degenerative diseases, cancer and repair of
damaged tissues for which there are currently no or limited therapeutic options. The …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …