This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

The ends of eukaryotic chromosomes have the potential to be mistaken for damaged or
broken DNA and must therefore be protected from cellular DNA damage response …

Introns are ubiquitous features of all eukaryotic cells. Introns need to be removed from
nascent messenger RNA through the process of splicing to produce functional proteins …

Telomere erosion and subsequent dysfunction limits the proliferation of normal human cells
by a process termed replicative senescence. Replicative senescence is thought to suppress …

The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here,
we show that the human telomeric protein TRF2 plays a key role in the protective activity of …

Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions
at the ends of macronuclear chromosomes. We have now identified homologous proteins in …

The chromosomes of lower eukaryotes have short telomeric 3′ extensions. Using a primer-
extension/nick-translation technique and nondenaturing hybridization, we find long 3′ G …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomeres protect the ends of linear chromosomes from degradation and abnormal
recombination events, and in vertebrates may be important in cellular senescence and …

Telomeres are the components of chromosome ends that provide stability and allow the
complete replication of the ends. Telomere length is maintained by a balance between …