[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

Oxidative stress and cognitive decline: the neuroprotective role of natural antioxidants

F Franzoni, G Scarfò, S Guidotti, J Fusi… - Frontiers in …, 2021 - frontiersin.org
Free-radicals (Oxygen and Nitrogen species) are formed in mitochondria during the
oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an …

Health Benefits of Silybum marianum: Phytochemistry, Pharmacology, and Applications

X Wang, Z Zhang, SC Wu - Journal of agricultural and food …, 2020 - ACS Publications
Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

Inorganic nanoparticles applied as functional therapeutics

Q Liu, YJ Kim, GB Im, J Zhu, Y Wu… - Advanced Functional …, 2021 - Wiley Online Library
Inorganic nanoparticles (NPs) offer significant advantages to the biomedical field owing to
their large surface area, controllable structures, diverse surface chemistry, and unique …

Nitric oxide/nitric oxide synthase system in the pathogenesis of neurodegenerative disorders—an overview

OM Iova, GE Marin, I Lazar, I Stanescu, G Dogaru… - Antioxidants, 2023 - mdpi.com
Nitric oxide, a ubiquitous molecule found throughout the natural world, is a key molecule
implicated in many central and benefic molecular pathways and has a well-established role …

Targeting iNOS alleviates early brain injury after experimental subarachnoid hemorrhage via promoting ferroptosis of M1 microglia and reducing neuroinflammation

W Qu, Y Cheng, W Peng, Y Wu, T Rui, C Luo… - Molecular …, 2022 - Springer
Numerous studies have demonstrated the role of neuroinflammation in mediating acute
pathophysiological events of early brain injury after subarachnoid hemorrhage (SAH) …

Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy

D Tewari, S Bawari, S Sharma, LK DeLiberto… - Pharmacology & …, 2021 - Elsevier
Emerging scientific evidence indicates that inflammation is a critical component of tumor
promotion and progression. Most cancers originate from sites of chronic irritation, infections …

The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions

JR Steinert, H Amal - Free Radical Biology and Medicine, 2023 - Elsevier
Nitric oxide and other redox active molecules such as oxygen free radicals provide essential
signalling in diverse neuronal functions, but their excess production and insufficient …

The effectiveness of L-arginine in clinical conditions associated with hypoxia

N Kurhaluk - International journal of molecular sciences, 2023 - mdpi.com
The review summarises the data of the last 50 years on the effectiveness of the amino acid L-
arginine in therapeutic practice in conditions accompanied by different-origin hypoxia. The …

Glutamatergic neurotransmission: A potential pharmacotherapeutic target for the treatment of cognitive disorders

P Chakraborty, A Dey, AV Gopalakrishnan… - Ageing Research …, 2023 - Elsevier
In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …