Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

Scarring is part of the normal healing response to tissue injury in all organs and required to
rapidly repair acute damages, mostly with extracellular matrix. A variety of different cells are …

The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

Cysteine cathepsins have been for a long time considered to execute mainly nonspecific
bulk proteolysis in the endolysosomal system. However, this view has been changing …

Abstract This issue of Matrix Biology is devoted to exploring how metalloproteinases–here
inclusive of related families of extracellular proteinases–act on extracellular matrix (ECM) …

In addition to providing a macromolecular scaffold, the extracellular matrix (ECM) is a critical
regulator of cell function by virtue of specific physical, biochemical, and mechanical …

The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …

Organ fibrosis is characterized by epithelial injury and aberrant tissue repair, where
activated effector cells, mostly fibroblasts and myofibroblasts, excessively deposit collagen …

Extracellular matrix (ECM) determines the physiological function of all tissues, including
musculoskeletal tissues. In tendon, ECM provides overall tissue architecture, which is …

Abstract Fos-related antigen-2 (Fra-2) belongs to the activator protein 1 (AP-1) family of
transcription factors and is involved in a broad variety of cellular processes, such as …