Mitochondrial dynamics in health and disease: mechanisms and potential targets

W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Q Chen, P Shou, C Zheng, M Jiang, G Cao… - Cell Death & …, 2016 - nature.com
Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Energy metabolism of the osteoblast: implications for osteoporosis

WC Lee, AR Guntur, F Long, CJ Rosen - Endocrine reviews, 2017 - academic.oup.com
Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …

The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review

F Atashi, A Modarressi, MS Pepper - Stem cells and development, 2015 - liebertpub.com
Mesenchymal stromal cells (MSCs) are promising candidates for tissue engineering and
regenerative medicine. The multipotent stem cell component of MSC isolates is able to …

The role of adipose tissue mitochondria: regulation of mitochondrial function for the treatment of metabolic diseases

JH Lee, A Park, KJ Oh, SC Lee, WK Kim… - International journal of …, 2019 - mdpi.com
Mitochondria play a key role in maintaining energy homeostasis in metabolic tissues,
including adipose tissues. The two main types of adipose tissues are the white adipose …

The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

L Han, B Wang, R Wang, S Gong, G Chen… - Stem cell research & …, 2019 - Springer
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several
tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological …

Effects of oxidative stress on mesenchymal stem cell biology

RA Denu, P Hematti - Oxidative medicine and cellular longevity, 2016 - Wiley Online Library
Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …

Mitochondrial transfer and regulators of mesenchymal stromal cell function and therapeutic efficacy

A Mohammadalipour, SP Dumbali… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding
microenvironment in both normal physiology and pathological conditions. While MSCs …

Connecting mitochondria, metabolism, and stem cell fate

A Wanet, T Arnould, M Najimi… - Stem cells and …, 2015 - liebertpub.com
As sites of cellular respiration and energy production, mitochondria play a central role in cell
metabolism. Cell differentiation is associated with an increase in mitochondrial content and …

The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

Q Li, Z Gao, Y Chen, MX Guan - Protein & cell, 2017 - Springer
Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged
as important tools for tissue engineering due to their differentiation potential along various …