Red blood cell (RBC) transfusions can be life‐sustaining in chronic inherited anaemias,
such as thalassaemia, and the indications for blood transfusions in patients with sickle cell …

Red blood cell (RBC) transfusions are a milestone in the treatment for sickle cell anaemia
(SSA) and for thalassaemia. RBC alloimmunization remains a major challenge of chronic …

Transfusion therapy is effective in the prevention and treatment of many complications of
sickle cell disease (SCD). However, its benefits must be balanced against its risks, including …

Background Transfusion is a cornerstone of the management of sickle cell disease but
carries a high risk of hemolytic transfusion reaction, probably because of differences in …

Understanding the complex immunological consequences of red cell transfusion is essential
if we are to use this valuable resource wisely and safely. The decision to transfuse red cells …

Background Globally, sickle cell disease (SCD) is one of the commonest severe monogenic
disorders, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD …

Background Sickle cell disease (SCD) is one of the commonest severe monogenic disorders
in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD …

The main side-effect of transfusion is alloimunization against red blood cell (RBC) antigens.
Thirteen percent of the general population were shown to be responders and 30% of …

BACKGROUND Delayed hemolytic transfusion reaction (DHTR) with hyperhemolysis is a
potentially fatal complication resulting from alloimmunization that can cause severe …

Sickle cell disease (SCD) is the most common monogenic disorder in sub-Saharan Africa
(SSA). Blood transfusion to increase the oxygen carrying capacity of blood is vital in the …