Enveloped viruses escape infected cells by budding through limiting membranes. In the
decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

Lipids and the membranes they form are fundamental building blocks of cellular life, and
their geometry and chemical properties distinguish membranes from other cellular …

Although the human immunodeficiency virus type 1 lipid envelope has been reported to be
enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the …

Tetherin, an interferon-inducible membrane protein, inhibits the release of nascent
enveloped viral particles from the surface of infected cells. However, the mechanisms …

Abstract Tetherin (BST2/CD317) has emerged as a key host cell defense molecule,
inhibiting the release and spread of diverse enveloped virions from infected cells. In this …

The HIV-1 envelope glycoprotein (Env) is sparsely incorporated onto assembling virus
particles on the host cell plasma membrane in order for the virus to balance infectivity and …

In the last year the COVID19 pandemic clearly illustrated the potential threat that viruses
pose to our society. The characterization of viral structures and the identification of key …

Retroviruses selectively incorporate a specific subset of host cell proteins and lipids into
their outer membrane when they bud out from the host plasma membrane. This specialized …

The matrix (MA) domain of HIV-1 mediates proper Gag localization and membrane binding
via interaction with a plasma-membrane (PM)-specific acidic phospholipid …