Shortly after the discovery of the first antibiotics, bacterial resistance began to emerge. Many
mechanisms give rise to resistance; the most prevalent mechanism of resistance to the …

Fluorescent indicator displacement (FID) assays are an advantageous approach to convert
receptors into optical sensors that can detect binding of various ligands. In particular, the …

Despite their clinical importance, saving numerous human lifes, over-and mis-uses of
antibiotics have created a strong selective pressure on bacteria, which induces the …

NMR spectroscopy is a powerful technique for separating and measuring each distinct p K a
value of the amino groups around aminoglycoside antibiotics. Unambiguous assignments …

Macrozones are novel conjugates of azithromycin and thiosemicarbazones, which exhibit
very good in vitro antibacterial activities against susceptible and some resistant bacterial …

A triplex-forming PNA oligomer conjugated with a naphthyridine derivative (ATMND-C2-
NH2) showed high selectivity and strong binding for the bacterial rRNA A-site at pH 7.0 (Kd …

We report that TO-PRO-3, a thiazole orange analogue with a trimethine bridge, functions as
a deep-red fluorescent indicator for the internal loop structure of the bacterial (Escherichia …

A 215-member mono-and diamino acid peptidic-aminosugar (PA) library, with neomycin as
the model aminosugar, was systematically and rapidly synthesized via solid phase …

MicroRNAs (miRs) are a class of endogenously expressed non-coding RNAs that negatively
regulate gene expression within cells and participate in maintaining cellular homeostasis …

Worldwide, bacterial antibiotic resistance continues to outpace the level of drug
development. One way to counteract this threat to society is to identify novel ways to rapidly …