pH sensing and regulation in cancer
Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and
deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an …
deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an …
Tumor pH and metastasis: a malignant process beyond hypoxia
O Thews, A Riemann - Cancer and Metastasis Reviews, 2019 - Springer
Tumors often show, compared to normal tissues, a markedly decreased extracellular pH
resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of …
resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of …
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands
Abstract In 2005, the International Union of Basic and Clinical Pharmacology Committee on
Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of …
Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of …
Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons
Blood gas and tissue pH regulation depend on the ability of the brain to sense CO2 and/or
H+ and alter breathing appropriately, a homeostatic process called central respiratory …
H+ and alter breathing appropriately, a homeostatic process called central respiratory …
[HTML][HTML] The impact of tumour pH on cancer progression: strategies for clinical intervention
C Ward, J Meehan, ME Gray, AF Murray… - … of Targeted Anti …, 2020 - ncbi.nlm.nih.gov
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities
for therapeutic intervention. The acidic microenvironment within a tumour can promote …
for therapeutic intervention. The acidic microenvironment within a tumour can promote …
Regulation of inflammation by extracellular acidification and proton-sensing GPCRs
F Okajima - Cellular signalling, 2013 - Elsevier
Under ischemic and inflammatory circumstances, such as allergic airway asthma,
rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the …
rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the …
Defining cancer subpopulations by adaptive strategies rather than molecular properties provides novel insights into intratumoral evolution
A Ibrahim-Hashim, M Robertson-Tessi… - Cancer research, 2017 - AACR
Ongoing intratumoral evolution is apparent in molecular variations among cancer cells from
different regions of the same tumor, but genetic data alone provide little insight into …
different regions of the same tumor, but genetic data alone provide little insight into …
Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis
Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic
organs, sickle cell disease, and many other pathological conditions due to hypoxia …
organs, sickle cell disease, and many other pathological conditions due to hypoxia …
Anti-Tumor Activity of Hypericum perforatum L. and Hyperforin through Modulation of Inflammatory Signaling, ROS Generation and Proton Dynamics
M Menegazzi, P Masiello, M Novelli - Antioxidants, 2020 - mdpi.com
In this paper we review the mechanisms of the antitumor effects of Hypericum perforatum
L.(St. John's wort, SJW) and its main active component hyperforin (HPF). SJW extract is …
L.(St. John's wort, SJW) and its main active component hyperforin (HPF). SJW extract is …