BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

The overall success of human reproduction, either spontaneously or after IVF, is highly
dependent upon maternal age. The main reasons for age-related infertility include reduced …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Female reproductive capacity declines dramatically in the fourth decade of life as a result of
an age‐related decrease in oocyte quality and quantity. The primary causes of reproductive …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

BACKGROUND Chromosomal mosaicism, the presence of two or more distinct cell lines, is
prevalent throughout human pre-and post-implantation development and can lead to …

Dramatic maturational changes occur in cardiac energy metabolism during cardiac
development, differentiation, and postnatal growth. These changes in energy metabolism …

The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from …

Mitochondria are found in all eukaryotic cells and contain their own genome (mitochondrial
DNA or mtDNA). Unlike the nuclear genome, which is derived from both the egg and sperm …