High content screening (HCS) combines the efficiency of high-throughput techniques with
the ability of cellular imaging to collect quantitative data from complex biological systems …

RNA interference (RNAi) is an effective tool for genome-scale, high-throughput analysis of
gene function. In the past five years, a number of genome-scale RNAi high-throughput …

The Plasmodium liver stage is an attractive target for the development of antimalarial drugs
and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a …

The term “high-content screening” has become synonymous with imaging screens using
automated microscopes and automated image analysis. The term was coined a little over 10 …

The first obligatory phase of mammalian infection by Plasmodium parasites, the causative
agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears …

Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases
caused by viruses and intracellular bacteria, but its implementation in the context of parasitic …

Plasmodium parasites undergo a clinically silent and obligatory developmental phase in the
host's liver cells before they are able to infect erythrocytes and cause malaria symptoms. To …

A major obstacle in analyzing gene function in apicomplexan parasites is the absence of a
practical regulatable expression system. Here, we identified functional transcriptional …

Background The possible emergence of resistance to the only available drug for
schistosomiasis spurs drug discovery that has been recently incentivized by the availability …

Background Plasmodium sporozoites migrate to the liver where they traverse several
hepatocytes before invading the one inside which they will develop and multiply into …