Isoflavones: estrogenic activity, biological effect and bioavailability

DC Vitale, C Piazza, B Melilli, F Drago… - European journal of drug …, 2013 - Springer
Isoflavones are phytoestrogens with potent estrogenic activity; genistein, daidzein and
glycitein are the most active isoflavones found in soy beans. Phytoestrogens have similarity …

First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics

B Wu, K Kulkarni, S Basu, S Zhang, M Hu - Journal of pharmaceutical …, 2011 - Elsevier
Glucuronidation mediated by UDP-glucuronosyltransferases (UGTs) is a significant
metabolic pathway that facilitates efficient elimination of numerous endobiotics and …

Bioaccessibility and bioavailability of phenolic compounds

F Shahidi, H Peng - Journal of Food Bioactives, 2018 - isnff-jfb.com
Modern epidemiological and interventional studies have demonstrated that various
bioactivities including antioxidant, antiproliferative, immune-regulatory, hormonal-regulation …

[图书][B] Handbook of nutraceuticals and functional foods

REC Wildman, R Wildman, TC Wallace - 2016 - taylorfrancis.com
Scientific advances in this field have not only given us a better understanding of what is an
optimal diet, but has allowed food and nutraceutical companies to market products with …

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

Z Guo, Y Lou, M Kong, Q Luo, Z Liu, J Wu - International journal of …, 2019 - mdpi.com
Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines.
Modern pharmacological studies and clinical practices indicate that AR possesses various …

Methylated flavonoids have greatly improved intestinal absorption and metabolic stability

X Wen, T Walle - Drug metabolism and disposition, 2006 - ASPET
To better understand the relationship between the chemical structure and biological fate of
dietary polyphenols, the hepatic metabolic stability and intestinal absorption of methylated …

Bioavailability challenges associated with development of anti-cancer phenolics

S Gao, M Hu - Mini reviews in medicinal chemistry, 2010 - ingentaconnect.com
Phenolics including many polyphenols and flavonoids have the potentials to become
chemoprevention and chemotherapy agents. However, poor bioavailability limits their …

Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME

Z Yang, K Kulkarni, W Zhu, M Hu - Anti-Cancer Agents in …, 2012 - ingentaconnect.com
Genistein, one of the most active natural flavonoids, exerts various biological effects
including chemoprevention, antioxidation, antiproliferation and anticancer. More than 30 …

Bioavailability issues in studying the health effects of plant polyphenolic compounds

CS Yang, S Sang, JD Lambert… - Molecular nutrition & food …, 2008 - Wiley Online Library
Polyphenolic compounds are common in the diet and have been suggested to have a
number of beneficial health effects including prevention of cancer, cardiovascular disease …

Dietary flavonoids for immunoregulation and cancer: Food design for targeting disease

JH Ahn-Jarvis, A Parihar, AI Doseff - Antioxidants, 2019 - mdpi.com
Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables,
have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory, and …