Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …

Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of
breast cancer is familial, referring to affected women who have one or more first-or second …

Defects in DNA repair genes have been extensively associated with cancer susceptibility.
Germline pathogenic variants (GPV) in genes involved in homologous recombination repair …

Interindividual differences in DNA repair systems may play a role in modulating the
individual risk of developing colorectal cancer. To better ascertain the role of DNA repair …

Background Genome-wide association studies (GWASs) have identified numerous single-
nucleotide polymorphisms (SNPs) associated with small increases in breast cancer risk …

The proficiency of cancer cells to repair DNA double-strand breaks (DSBs) by homologous
recombination (HR) is a key determinant in predicting response to targeted therapies such …

Die Behandlung des metastasierten Mammakarzinoms hat bei immer neu zu testenden
Therapien deutlich an Komplexität zugenommen. Therapien werden nunmehr nur noch für …

Decades of research have shown that rare highly penetrant mutations can promote
tumorigenesis, but it is still unclear whether variants observed at high-frequency in the …

Hereditary predisposition to cancer concerns between 5% and 10% of cancers. The main
genes involved in the most frequent syndromes (hereditary breast and ovarian cancer …

Résumé Introduction Dans le contexte d'une suspicion de prédisposition aux cancers du
sein et de l'ovaire, le séquençage haut débit permet désormais d'analyser de nombreux …