Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Hypoxia is a hallmark of all solid tumors and their metastases. This leads to activation of the
hypoxia-inducible factor (HIF) family of transcription factors, which modulate gene …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a master driver of glucose metabolism in
cancer cells. Here, we demonstrate that a HIF-1α anti-sense lncRNA, HIFAL, is essential for …

The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible
factor (HIF) transcription factors; these play an integral role in the metabolic changes that …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

T cell differentiation into distinct functional effector and inhibitory subsets is regulated, in
part, by the cytokine environment present at the time of antigen recognition. Here, we show …

The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the
PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes …

Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important
for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical …

SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with
various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop …