Oocyte activation deficiency: a role for an oocyte contribution?
BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation
G Campos, R Sciorio, SC Esteves - Human reproduction update, 2023 - academic.oup.com
BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …
[HTML][HTML] Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice
C Song, W Peng, S Yin, J Zhao, B Fu, J Zhang, T Mao… - Scientific reports, 2016 - nature.com
Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …
oxidative damage. However, the protective effects of melatonin against ovarian aging has …
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence
Activation of the egg by the sperm is the first, vital stage of embryogenesis. The sperm
protein PLCζ has been proposed as the physiological agent that triggers the Ca2+ …
protein PLCζ has been proposed as the physiological agent that triggers the Ca2+ …
Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application
BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSI
M Torra-Massana, D Cornet-Bartolomé… - Human …, 2019 - academic.oup.com
Abstract STUDY QUESTION Are phospholipase C zeta 1 (PLCZ1) mutations associated with
fertilization failure (FF) after ICSI? SUMMARY ANSWER New mutations in the PLCZ1 …
fertilization failure (FF) after ICSI? SUMMARY ANSWER New mutations in the PLCZ1 …
[HTML][HTML] Sperm-oocyte interplay: an overview of spermatozoon's role in oocyte activation and current perspectives in diagnosis and fertility treatment
MI Zafar, S Lu, H Li - Cell & bioscience, 2021 - Springer
The fertilizing spermatozoon is a highly specialized cell that selects from millions along the
female tract until the oocyte. The paternal components influence the oocyte activation during …
female tract until the oocyte. The paternal components influence the oocyte activation during …
[HTML][HTML] Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic …
D Bonte, M Ferrer-Buitrago, L Dhaenens, M Popovic… - Fertility and …, 2019 - Elsevier
Objective To investigate the extent to which assisted oocyte activation (AOA) improves
clinical outcomes in patients diagnosed with oocyte activation deficiencies (OADs). Design …
clinical outcomes in patients diagnosed with oocyte activation deficiencies (OADs). Design …
[HTML][HTML] Assisted oocyte activation with calcium ionophore improves pregnancy outcomes and offspring safety in infertile patients: a systematic review and meta …
Y Shan, H Zhao, D Zhao, J Wang, Y Cui… - Frontiers in Physiology, 2022 - frontiersin.org
This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted
oocyte activation (AOA). This meta-analysis contained randomized controlled trials and …
oocyte activation (AOA). This meta-analysis contained randomized controlled trials and …
[HTML][HTML] Calcium ionophore (A23187) rescues the activation of unfertilized oocytes after intracytoplasmic sperm injection and chromosome analysis of blastocyst after …
Z Xu, G Yao, W Niu, H Fan, X Ma, S Shi… - Frontiers in …, 2021 - frontiersin.org
Calcium is a crucial factor in regulating the biological behavior of cells. The imbalance of
calcium homeostasis in cytoplasm will cause abnormal behavior of cells and the occurrence …
calcium homeostasis in cytoplasm will cause abnormal behavior of cells and the occurrence …