Little is known about the impact of comorbidities on multidrug resistant (MDR) and
extensively drug resistant (XDR) tuberculosis (TB) treatment outcomes. We aimed to …

Introduction Historically, extensively drug-resistant tuberculosis has been notoriously difficult
to treat with devasting outcomes. As we are coming to the end of an era where the 2006 …

Polyclonal infections occur when at least two unrelated strains of the same pathogen are
detected in an individual. This has been linked to worse clinical outcomes in tuberculosis, as …

Rates and risk factors for acquired drug resistance and association with outcomes among
patients with multidrug-resistant tuberculosis (MDR TB) are not well defined. In an MDR TB …

Emergence of extensively drug-resistant tuberculosis (XDR-TB) has significantly threatened
to jeopardize global efforts to control TB, especially in HIV endemic regions. XDR-TB is …

Improved knowledge regarding the tissue penetration of antituberculosis drugs may help
optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing …

Lung resections have been always the shortest way of removal of the affected zone of the
lung with the hope of future recovery of tuberculosis (TB) patients. Nevertheless the …

Background Post-treatment morbidity among subjects with drug-resistant tuberculosis (DR-
TB) is unclear. Methods This was a cross-sectional study of patients from Tbilisi, Georgia …

ABSTRACT A better understanding of second-line drug (SLD) pharmacokinetics, including
cavitary penetration, may help optimize SLD dosing. Patients with pulmonary multidrug …

Multidrug-resistant (MDR) and extensive drug-resistant (XDR) tuberculosis (TB) are
significant health problems throughout the world. Although the main treatment is medical …