Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …

The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Highlights•Cajal bodies have a definitive role in regulating the maturation of
snRNPs.•Numerous nuclear bodies contain scaffolding RNAs, including paraspeckles and …

It has been nearly 63 years since the first characterization of an RNA triple helix in vitro by
Gary Felsenfeld, David Davies, and Alexander Rich. An RNA triple helix consists of three …

Ribonucleoprotein enzymes require dynamic conformations of their RNA constituents for
regulated catalysis. Human telomerase employs a non-coding RNA (hTR) with a bipartite …

The vast body of literature regarding human telomere maintenance is a true testament to the
importance of understanding telomere regulation in both normal and diseased states. In this …

Telomeres facilitate the protection of natural ends of chromosomes from constitutive
exposure to the DNA damage response (DDR). This is most likely achieved by a lariat …

Extension of telomeres is a critical step in the immortalization of cancer cells. This complex
reaction requires proper spatiotemporal coordination of telomerase and telomeres and …