Global environmental issues and sustainable development call for new technologies for fine
chemical synthesis and waste valorization. Biocatalysis has attracted great attention as the …

ADP-ribosyltransferases use NAD+ to catalyse substrate ADP-ribosylation, and thereby
regulate cellular pathways or contribute to toxin-mediated pathogenicity of bacteria …

Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …

Nucleosides are ubiquitous to life and are required for the synthesis of DNA, RNA, and other
molecules crucial for cell survival. Despite the notoriously difficult organic synthesis of …

In this work, a mono-and a bi-enzymatic analytical immobilized enzyme reactors (IMERs)
were developed as prototypes for biosynthetic purposes and their performances in the in …

Directed enzyme prodrug therapy (DEPT) strategies show promise in mitigating
chemotherapy side effects during cancer treatment. Among these, the use of immobilized …

One of the major drawbacks of the industrial implementation of enzymatic processes is the
low operational stability of the enzymes under tough industrial conditions. In this respect, the …

Glycosyl cations are key intermediates in the glycosylation reactions taking place through a
SN1-type mechanism. To obtain a reliable description of the glycosylation reaction …

The prediction of enzyme activity is one of the main challenges in catalysis. With computer-
aided methods, it is possible to simulate the reaction mechanism at the atomic level …

2ʹ-Ribonucleosides are essential building blocks used extensively in antiviral and
oligonucleotide therapeutics. A major challenge in the further development of nucleoside …