Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or
progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH) …

Background Bevacizumab is approved for the treatment of patients with progressive
glioblastoma on the basis of uncontrolled data. Data from a phase 2 trial suggested that the …

Background Glioblastoma multiforme (GBM) is the most common cancer of the central
nervous system, while Parkinson's disease (PD) is a degenerative neurological condition …

Glioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors,
characterized by malignant growth, invasion into the brain parenchyma, and resistance to …

The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …

Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …

The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …

Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to
their malignant growth and invasion into the brain parenchyma coupled with resistance to …