Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Endothelial cells adopt tissue-specific characteristics to instruct organ development and
regeneration,. This adaptability is lost in cultured adult endothelial cells, which do not …

Native pancreatic islets interact with neighboring cells by establishing three-dimensional
(3D) structures, and are surrounded by perfusion at an interstitial flow level. However, flow …

Clinical transplantation of tissue fragments, including islets, faces a critical challenge
because of a lack of effective strategies that ensure efficient engraftment through the timely …

Levels of obesity have reached epidemic proportions on a global scale, which has led to
considerable increases in health problems and increased risk of several diseases, including …

We propose a network representation of electrically coupled beta cells in islets of
Langerhans. Beta cells are functionally connected on the basis of correlations between …

The expeditious advancement in the organ on chip technology provided a phase change to
the conventional in vitro tests used to evaluate absorption, distribution, metabolism …

Here, we demonstrate that the fractalkine (FKN)/CX3CR1 system represents a regulatory
mechanism for pancreatic islet β cell function and insulin secretion. CX3CR1 knockout (KO) …

Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy
homeostasis, stress protection and angiogenesis, but the underlying mechanisms are …