Malaria: biology and disease
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …
cause of death and disease across many tropical and subtropical countries. Over the last …
Variant surface antigens of Plasmodium falciparum and their roles in severe malaria
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
PTEX is an essential nexus for protein export in malaria parasites
B Elsworth, K Matthews, CQ Nie, M Kalanon… - Nature, 2014 - nature.com
During the blood stages of malaria, several hundred parasite-encoded proteins are exported
beyond the double-membrane barrier that separates the parasite from the host cell …
beyond the double-membrane barrier that separates the parasite from the host cell …
A newly discovered protein export machine in malaria parasites
Several hundred malaria parasite proteins are exported beyond an encasing vacuole and
into the cytosol of the host erythrocyte, a process that is central to the virulence and viability …
into the cytosol of the host erythrocyte, a process that is central to the virulence and viability …
Plasmodium species: master renovators of their host cells
Plasmodium parasites, the causative agents of malaria, have developed elaborate
strategies that they use to survive and thrive within different intracellular environments …
strategies that they use to survive and thrive within different intracellular environments …
[HTML][HTML] Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes
A major part of virulence for Plasmodium falciparum malaria infection, the most lethal
parasitic disease of humans, results from increased rigidity and adhesiveness of infected …
parasitic disease of humans, results from increased rigidity and adhesiveness of infected …
New insights into the blood‐stage transcriptome of Plasmodium falciparum using RNA‐Seq
Recent advances in high‐throughput sequencing present a new opportunity to deeply probe
an organism's transcriptome. In this study, we used Illumina‐based massively parallel …
an organism's transcriptome. In this study, we used Illumina‐based massively parallel …
Malaria parasite proteins that remodel the host erythrocyte
Exported proteins of the malaria parasite Plasmodium falciparum interact with proteins of the
erythrocyte membrane and induce substantial changes in the morphology, physiology and …
erythrocyte membrane and induce substantial changes in the morphology, physiology and …
An aspartyl protease directs malaria effector proteins to the host cell
Plasmodium falciparum causes the virulent form of malaria and disease manifestations are
linked to growth inside infected erythrocytes. To survive and evade host responses the …
linked to growth inside infected erythrocytes. To survive and evade host responses the …
Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
I Russo, S Babbitt, V Muralidharan, T Butler, A Oksman… - Nature, 2010 - nature.com
During their intraerythrocytic development, malaria parasites export hundreds of proteins to
remodel their host cell. Nutrient acquisition, cytoadherence and antigenic variation are …
remodel their host cell. Nutrient acquisition, cytoadherence and antigenic variation are …