Malaria: biology and disease

AF Cowman, J Healer, D Marapana, K Marsh - Cell, 2016 - cell.com
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

M Wahlgren, S Goel, RR Akhouri - Nature Reviews Microbiology, 2017 - nature.com
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

PTEX is an essential nexus for protein export in malaria parasites

B Elsworth, K Matthews, CQ Nie, M Kalanon… - Nature, 2014 - nature.com
During the blood stages of malaria, several hundred parasite-encoded proteins are exported
beyond the double-membrane barrier that separates the parasite from the host cell …

A newly discovered protein export machine in malaria parasites

TF de Koning-Ward, PR Gilson, JA Boddey, M Rug… - Nature, 2009 - nature.com
Several hundred malaria parasite proteins are exported beyond an encasing vacuole and
into the cytosol of the host erythrocyte, a process that is central to the virulence and viability …

Plasmodium species: master renovators of their host cells

TF de Koning-Ward, MWA Dixon, L Tilley… - Nature Reviews …, 2016 - nature.com
Plasmodium parasites, the causative agents of malaria, have developed elaborate
strategies that they use to survive and thrive within different intracellular environments …

[HTML][HTML] Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

AG Maier, M Rug, MT O'Neill, M Brown, S Chakravorty… - Cell, 2008 - cell.com
A major part of virulence for Plasmodium falciparum malaria infection, the most lethal
parasitic disease of humans, results from increased rigidity and adhesiveness of infected …

New insights into the blood‐stage transcriptome of Plasmodium falciparum using RNA‐Seq

TD Otto, D Wilinski, S Assefa, TM Keane… - Molecular …, 2010 - Wiley Online Library
Recent advances in high‐throughput sequencing present a new opportunity to deeply probe
an organism's transcriptome. In this study, we used Illumina‐based massively parallel …

Malaria parasite proteins that remodel the host erythrocyte

AG Maier, BM Cooke, AF Cowman… - Nature Reviews …, 2009 - nature.com
Exported proteins of the malaria parasite Plasmodium falciparum interact with proteins of the
erythrocyte membrane and induce substantial changes in the morphology, physiology and …

An aspartyl protease directs malaria effector proteins to the host cell

JA Boddey, AN Hodder, S Günther, PR Gilson… - Nature, 2010 - nature.com
Plasmodium falciparum causes the virulent form of malaria and disease manifestations are
linked to growth inside infected erythrocytes. To survive and evade host responses the …

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

I Russo, S Babbitt, V Muralidharan, T Butler, A Oksman… - Nature, 2010 - nature.com
During their intraerythrocytic development, malaria parasites export hundreds of proteins to
remodel their host cell. Nutrient acquisition, cytoadherence and antigenic variation are …