The alarming rise in drug-resistant clinical cases of tuberculosis (TB) has necessitated the
rapid development of newer chemotherapeutic agents with novel mechanisms of action. The …

Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are
sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard …

Tuberculosis (TB) remains a serious threat to global public health, responsible for an
estimated 1.5 million mortalities in 2018. While there are available therapeutics for this …

We report on the virtual screening, synthesis, and biological evaluation of new furan
derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). A receptor …

Highlights•Menaquinones (MKs) are involved in bacterial electron transport and
adaptation.•The Men pathway is the most predominant of two bacterial pathways to make …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is the most significant
cause of death from a single infectious agent worldwide. Antibiotic-resistant strains of M …

Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …

Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …

Traditional hit-to-lead optimization assumes that upon elaboration of chemical structure, the
ligand retains its binding mode relative to the receptor. Here, we build a large-scale …