Ciprofloxacin derivatives and their antibacterial activities
GF Zhang, X Liu, S Zhang, B Pan, ML Liu - European journal of medicinal …, 2018 - Elsevier
Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …
majority of hospital-acquired infections, leading to extensive mortality and burden on global …
4-Quinolone hybrids and their antibacterial activities
YQ Hu, S Zhang, Z Xu, ZS Lv, ML Liu… - European Journal of …, 2017 - Elsevier
The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant
and pan-drug resistant pathogens which are associated with considerable mortality …
and pan-drug resistant pathogens which are associated with considerable mortality …
4-Quinolone derivatives and their activities against Gram positive pathogens
GF Zhang, S Zhang, B Pan, X Liu, LS Feng - European Journal of Medicinal …, 2018 - Elsevier
Gram-positive bacteria are responsible for a broad range of infectious diseases, and the
emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA …
emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA …
Recent developments of quinolone-based derivatives and their activities against Escherichia coli
F Gao, P Wang, H Yang, Q Miao, L Ma, G Lu - European Journal of …, 2018 - Elsevier
Escherichia coli (E. coli) is the most common pathogen in both hospital and community
settings, and is capable of causing infections that can lead to serious consequences …
settings, and is capable of causing infections that can lead to serious consequences …
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part …
New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit
ovine COX-1/COX-2 isozymes was evaluated using in vitro cyclooxygenase (COX) inhibition …
ovine COX-1/COX-2 isozymes was evaluated using in vitro cyclooxygenase (COX) inhibition …
Design, synthesis, and antitumor activity of novel compounds based on 1, 2, 4-triazolophthalazine scaffold: apoptosis-inductive and PCAF-inhibitory effects
The antitumor activity of newly synthesised triazolophthalazines (L-45 analogues) 10–32
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
was evaluated in human hepatocellular carcinoma (HePG-2), breast cancer (MCF-7) …
Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies
The antitumor activity of newly synthesized 4-anilino-2-vinylquinazolines 8a-r was measured
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …
comparable to sorafenib as a standard drug. The 2-vinylquinazolines 8a-r were evaluated …
[HTML][HTML] Synthesis, antimicrobial activity, structure-activity relationship, and molecular docking studies of indole diketopiperazine alkaloids
B Jia, Y Ma, B Liu, P Chen, Y Hu, R Zhang - Frontiers in Chemistry, 2019 - frontiersin.org
Strategies for the synthesis of indole diketopiperazine alkaloids (indole DKPs) have been
described and involve three analogs of indole DKPs. The antimicrobial activity and structure …
described and involve three analogs of indole DKPs. The antimicrobial activity and structure …
Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
MAA El-Sayed, WM El-Husseiny… - Journal of enzyme …, 2018 - Taylor & Francis
Abstract A new series of 4, 6-disubstituted 2-(4-(dimethylamino) styryl) quinoline 4a, b–9a, b
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking
A new series of non-carboxylic naproxen analogues, bearing a variety of ring systems, such
as oxadiazoles 3a–c and 6a–c, cycloalkanes 4a–d, cyclic imides 5a–c, and triazoles 7–9 …
as oxadiazoles 3a–c and 6a–c, cycloalkanes 4a–d, cyclic imides 5a–c, and triazoles 7–9 …