Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design

DJ Berry, JW Steed - Advanced drug delivery reviews, 2017 - Elsevier
As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …

Recent advances in co-amorphous drug formulations

SJ Dengale, H Grohganz, T Rades… - Advanced drug delivery …, 2016 - Elsevier
Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …

Co-amorphous drug formulations in numbers: Recent advances in co-amorphous drug formulations with focus on co-formability, molar ratio, preparation methods …

J Liu, H Grohganz, K Löbmann, T Rades, NJ Hempel - Pharmaceutics, 2021 - mdpi.com
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery

A Karagianni, K Kachrimanis, I Nikolakakis - Pharmaceutics, 2018 - mdpi.com
The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

[HTML][HTML] Development of remdesivir as a dry powder for inhalation by thin film freezing

S Sahakijpijarn, C Moon, JJ Koleng, DJ Christensen… - Pharmaceutics, 2020 - mdpi.com
Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for
emergency use. To maximize delivery to the lungs, we formulated remdesivir as a dry …

[图书][B] Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development

R Hilfiker, M Von Raumer - 2019 - books.google.com
" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …

[HTML][HTML] Recent developments in the crystallization process: toward the pharmaceutical industry

Z Gao, S Rohani, J Gong, J Wang - Engineering, 2017 - Elsevier
Crystallization is one of the oldest separation and purification unit operations, and has
recently contributed to significant improvements in producing higher-value products with …

[HTML][HTML] Advances in coamorphous drug delivery systems

Q Shi, SM Moinuddin, T Cai - Acta pharmaceutica sinica B, 2019 - Elsevier
In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …

Development and Characterization of Fast Dissolving Buccal Strip of Frovatriptan Succinate Monoydrate for Buccal Delivery.

P Bhatt, S Singh, SK Sharma… - International Journal of …, 2021 - search.ebscohost.com
Objectives: Aim of the present research work is to prepared fast mouth dissolving film of
frovatriptan succinate monoydrate. Methods: Fast dissolving buccal film is prepared by …

Co amorphous systems: A product development perspective

RB Chavan, R Thipparaboina, D Kumar… - International journal of …, 2016 - Elsevier
Solubility is one of the major problems associated with most of the new chemical entities that
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …