Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design
As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …
efficient strategies for their property improvement become increasingly important to global …
Recent advances in co-amorphous drug formulations
Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
Co-amorphous drug formulations in numbers: Recent advances in co-amorphous drug formulations with focus on co-formability, molar ratio, preparation methods …
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …
or more (initially crystalline) low molecular weight components that form a homogeneous …
Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery
The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …
However, due to thermodynamic instability and recrystallization tendencies during …
[HTML][HTML] Development of remdesivir as a dry powder for inhalation by thin film freezing
S Sahakijpijarn, C Moon, JJ Koleng, DJ Christensen… - Pharmaceutics, 2020 - mdpi.com
Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for
emergency use. To maximize delivery to the lungs, we formulated remdesivir as a dry …
emergency use. To maximize delivery to the lungs, we formulated remdesivir as a dry …
[图书][B] Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development
R Hilfiker, M Von Raumer - 2019 - books.google.com
" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …
[HTML][HTML] Recent developments in the crystallization process: toward the pharmaceutical industry
Crystallization is one of the oldest separation and purification unit operations, and has
recently contributed to significant improvements in producing higher-value products with …
recently contributed to significant improvements in producing higher-value products with …
[HTML][HTML] Advances in coamorphous drug delivery systems
Q Shi, SM Moinuddin, T Cai - Acta pharmaceutica sinica B, 2019 - Elsevier
In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …
Development and Characterization of Fast Dissolving Buccal Strip of Frovatriptan Succinate Monoydrate for Buccal Delivery.
Objectives: Aim of the present research work is to prepared fast mouth dissolving film of
frovatriptan succinate monoydrate. Methods: Fast dissolving buccal film is prepared by …
frovatriptan succinate monoydrate. Methods: Fast dissolving buccal film is prepared by …
Co amorphous systems: A product development perspective
Solubility is one of the major problems associated with most of the new chemical entities that
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …