While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

The i-motif represents a paradigmatic example of the wide structural versatility of nucleic
acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held …

DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

Abstract Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can
be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences …

DNA sequences rich in cytosine have the propensity, under acidic pH, to fold into four‐
stranded intercalated DNA structures called i‐motifs. Recent studies have provided …

As non-canonical nucleic acid secondary structures consisting of cytosine-rich nucleic acids,
i-motifs can form under certain conditions. Several i-motif sequences have been identified in …

DNA-intercalated motifs (iMs) are facile scaffolds for the design of various pH-responsive
nanomachines, including biocompatible pH sensors. First, DNA pH sensors relied on …

The specificity and predictability of hybridization make oligonucleotides a powerful platform
to program assemblies and networks with logic-gated responses, an area of research which …

Telomeres are specialized structures, found at the ends of linear chromosomes in eukaryotic
cells, that play a crucial role in maintaining the stability and integrity of genomes. They are …

Stabilizing i-motif structures at neutral pH and physiological temperature remains a major
challenge. Here, we demonstrate the use of chemical end-ligation to stabilize intramolecular …