Skeletal muscle is the protein reservoir of our body and an important regulator of glucose
and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Mitochondrial quality control is essential in highly structured cells such as neurons and
muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

Abstract Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Muscle wasting is a consequence of physiological changes or a pathology characterized by
increased catabolic activity that leads to progressive loss of skeletal muscle mass and …

The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

Most patients with advanced solid cancers exhibit features of cachexia, a debilitating
syndrome characterized by progressive loss of skeletal muscle mass and strength. Because …

The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …