Dysphagia in Parkinson's disease

I Suttrup, T Warnecke - Dysphagia, 2016 - Springer
More than 80% of patients with Parkinson's disease (PD) develop dysphagia during the
course of their disease. Swallowing impairment reduces quality of life, complicates …

Animal behavioral assessments in current research of Parkinson's disease

T Asakawa, H Fang, K Sugiyama, T Nozaki… - Neuroscience & …, 2016 - Elsevier
Abstract Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified
as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently …

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease

T Uehara, CJ Choong, M Nakamori, H Hayakawa… - Scientific reports, 2019 - nature.com
Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of
dopaminergic neurons in the substantia nigra. A characteristic pathological feature of PD is …

Evidence for early and progressive ultrasonic vocalization and oromotor deficits in a PINK1 gene knockout rat model of Parkinson's disease

LM Grant, CA Kelm‐Nelson, BL Hilby… - Journal of …, 2015 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative disease that leads to a wide
range of motor and nonmotor deficits. Specifically, voice and swallow deficits manifest early …

New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease

IV Ekimova, DV Plaksina, YF Pastukhov… - Experimental …, 2018 - Elsevier
Abstract Molecular chaperone HSP70 (HSPA1A) has therapeutic potential in conformational
neurological diseases. Here we evaluate the neuroprotective function of the chaperone in a …

Rat models of vocal deficits in Parkinson's disease

MN Krasko, JD Hoffmeister, NE Schaen-Heacock… - Brain Sciences, 2021 - mdpi.com
Parkinson's disease (PD) is a progressive, degenerative disorder that affects 10 million
people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a …

Docosahexaenoic acid protects motor function and increases dopamine synthesis in a rat model of Parkinson's disease via mechanisms associated with increased …

NM Chitre, BJ Wood, A Ray, NH Moniri, KS Murnane - Neuropharmacology, 2020 - Elsevier
Parkinson's disease (PD) is a devastating neurodegenerative disease that leads to motor
deficits and selective destruction of nigrostriatal dopaminergic neurons. PD is typically …

Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice

R Rabl, C Breitschaedel, S Flunkert, S Duller… - BMC neuroscience, 2017 - Springer
Abstract Background Synucleinopathies such as Parkinson's disease or multiple system
atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are …

Videofluorographic assessment of deglutitive behaviors in a rat model of aging and Parkinson disease

JA Russell, MR Ciucci, MJ Hammer, NP Connor - Dysphagia, 2013 - Springer
Dysphagia is commonly associated with aging and Parkinson disease and can have a
significant impact on a person's quality of life. In some cases, dysphagia may be life …

Tongue and laryngeal exercises improve tongue strength and vocal function outcomes in a Pink1-/-rat model of early Parkinson disease

CK Broadfoot, JD Hoffmeister, SA Lechner… - Behavioural Brain …, 2024 - Elsevier
Parkinson disease (PD) causes voice and swallow dysfunction even in early stages of the
disease. Treatment of this dysfunction is limited, and the neuropathology underlying this …