Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are
involved in myriad cellular processes. Their distribution in various cellular compartments …

Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …

Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …