Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …

Glomerular Filtration and Albuminuria Chronic kidney diseases generally arise from a
disordered kidney filtration barrier within glomeruli. This review describes the roles of …

Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

Liquid-liquid phase separation, driven by collective interactions among multivalent and
intrinsically disordered proteins, is thought to mediate the formation of membrane-less …

Biomolecular condensation is emerging as an essential process for cellular
compartmentalization. The formation of biomolecular condensates can be driven by liquid …

Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

Background: Podocyte biology is a developing science that promises to help improve
understanding of the mechanistic nature of multiple diseases associated with proteinuria …

Cells are organized on length scales ranging from ångström to micrometres. However, the
mechanisms by which ångström-scale molecular properties are translated to micrometre …