More tricks with tetramers: a practical guide to staining T cells with peptide–MHC multimers
Analysis of antigen‐specific T‐cell populations by flow cytometry with peptide–MHC (pMHC)
multimers is now commonplace. These reagents allow the tracking and phenotyping of T …
multimers is now commonplace. These reagents allow the tracking and phenotyping of T …
[HTML][HTML] DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer
N Luo, MJ Nixon, PI Gonzalez-Ericsson… - Nature …, 2018 - nature.com
Potentiating anti-tumor immunity by inducing tumor inflammation and T cell-mediated
responses are a promising area of cancer therapy. Immunomodulatory agents that promote …
responses are a promising area of cancer therapy. Immunomodulatory agents that promote …
The molecular determinants of CD 8 co‐receptor function
CD 8+ T cells respond to signals mediated through a specific interaction between the T‐cell
receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between …
receptor (TCR) and a composite antigen in the form of an epitopic peptide bound between …
A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex
(MHC) and MHC class I–like molecules. We describe a diverse population of human γδ T …
(MHC) and MHC class I–like molecules. We describe a diverse population of human γδ T …
[HTML][HTML] Peptide–MHC class I tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations
Abstract Peptide-MHC (pMHC) multimers, usually used as streptavidin-based tetramers,
have transformed the study of Ag-specific T cells by allowing direct detection, phenotyping …
have transformed the study of Ag-specific T cells by allowing direct detection, phenotyping …
Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha–Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in …
Background: Rheumatic heart valve disease (RHVD) is a leading cause of cardiovascular
death in low-and middle-income countries and affects predominantly women. The …
death in low-and middle-income countries and affects predominantly women. The …
[HTML][HTML] Optimized peptide–MHC multimer protocols for detection and isolation of autoimmune T-cells
Peptide–MHC (pMHC) multimers have become the “gold standard” for the detection and
isolation of antigen-specific T-cells but recent evidence shows that normal use of these …
isolation of antigen-specific T-cells but recent evidence shows that normal use of these …
Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells
Fluorochrome-conjugated peptide–major histocompatibility complex (pMHC) multimers are
widely used for flow cytometric visualization of antigen-specific T cells. The most common …
widely used for flow cytometric visualization of antigen-specific T cells. The most common …
[HTML][HTML] Antibody stabilization of peptide–MHC multimers reveals functional T cells bearing extremely low-affinity TCRs
K Tungatt, V Bianchi, MD Crowther… - The Journal of …, 2015 - journals.aai.org
Fluorochrome-conjugated peptide–MHC (pMHC) multimers are commonly used in
combination with flow cytometry for direct ex vivo visualization and characterization of Ag …
combination with flow cytometry for direct ex vivo visualization and characterization of Ag …
[HTML][HTML] Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor …
M Kalaitsidou, OR Moon, M Sykorova, L Bao… - Frontiers in …, 2023 - frontiersin.org
Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory
melanoma has shown clinical efficacy in a number of trials. However, extending the clinical …
melanoma has shown clinical efficacy in a number of trials. However, extending the clinical …