The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological …

DC Steffens, M Fahed, KJ Manning, L Wang - Translational psychiatry, 2022 - nature.com
Apathy is a common condition that involves diminished initiative, diminished interest and
diminished emotional expression or responsiveness. It is highly prevalent in the context of a …

[HTML][HTML] Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer's Disease–Evidence from an MRI-based Meta-Analysis

M Mieling, H Meier, N Bunzeck - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Recent models of Alzheimer's Disease (AD) suggest that neuropathological changes of the
medial temporal lobe, especially entorhinal cortex, are preceded by degenerations of the …

A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia

LM Jenkins, L Wang, H Rosen, S Weintraub - Brain, 2022 - academic.oup.com
Apathy and disinhibition are common and highly distressing neuropsychiatric symptoms
associated with negative outcomes in persons with dementia. This paper is a critical review …

Altered reward processing underpins emotional apathy in dementia

S Wong, G Wei, M Husain, JR Hodges, O Piguet… - Cognitive, Affective, & …, 2023 - Springer
Introduction While apathy is broadly defined as a loss of motivation, it is increasingly
recognised as a multidimensional syndrome spanning executive, emotional, and initiation …

[图书][B] Vom Leben und Sterben im Alter: Wie wir das Lebensende gestalten können

A Kruse - 2021 - books.google.com
This book is concerned with people who are approaching the end of their lives, as well as
with the personal and professional caregivers who accompany them during this last stage. It …

Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia

SR Shaw, H El-Omar, D Roquet, JR Hodges, O Piguet… - Brain, 2021 - academic.oup.com
Much of human behaviour is motivated by the drive to experience pleasure. The capacity to
envisage pleasurable outcomes and to engage in goal-directed behaviour to secure these …

Multidimensional apathy in behavioral variant frontotemporal dementia, primary progressive aphasia, and Alzheimer disease

R Radakovic, S Colville, D Cranley… - Journal of geriatric …, 2021 - journals.sagepub.com
Apathy is prevalent in dementia, such as behavioral variant frontotemporal dementia
(bvFTD), primary progressive aphasia (PPA), and Alzheimer disease (AD). As a …

Apathy is associated with parietal cortical-subcortical dysfunction in ALS

J Caga, S Tu, T Dharmadasa, YT Nga, MC Zoing… - Cortex, 2021 - Elsevier
Apathy is the core behavioural feature of frontotemporal dysfunction in amyotrophic lateral
sclerosis (ALS). Initiation and emotional manifestations of apathy significantly affect patients …

The neural correlates of apathy in the context of aging and brain disorders: a meta-analysis of neuroimaging studies

H Yan, H Wu, Z Cai, S Du, L Li, B Xu… - Frontiers in aging …, 2023 - frontiersin.org
Introduction Apathy is a prevalent mood disturbance that occurs in a wide range of
populations, including those with normal cognitive aging, mental disorders …

Beyond language impairment: Profiles of apathy in primary progressive aphasia

H Quang, S Wong, M Husain, O Piguet, JR Hodges… - Cortex, 2021 - Elsevier
Primary progressive aphasia (PPA) is characterised by predominant language and
communication impairment. However, behavioural changes, such as apathy, are …