Background Immune checkpoint inhibitors have revolutionized cancer therapeutic paradigm
and substantially improved the survival of patients with advanced malignancies. However, a …

Despite decades of clinical and preclinical studies, the markers and mechanisms of
resistance to cancer immunotherapy, particularly immune checkpoint blockade (ICB), remain …

Immune checkpoint blockade (ICB) therapies exhibit substantial clinical benefit in different
cancers, but relatively low response rates in the majority of patients highlight the need to …

The cellular stress and immunity cycle is a cornerstone of organismal homeostasis. Stress
activates intracellular and intercellular communications within a tissue or organ to initiate …

Background: Cancer-induced mortality is increasingly prevalent globally, which skyrocketed
the necessity to discover new/novel, safe and effective anticancer drugs. Cancer is …

Immunotherapy profoundly changed oncology treatment, becoming one of the main
therapeutical strategies. Remarkable improvement has been achieved in survival outcomes …

Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with
advanced-stage hepatocellular carcinoma (HCC). Two different ICI-containing regimens …

Immune checkpoint inhibitors (ICIs) have revolutionized cancer management and have
been widely applied; however, they still have some limitations in terms of efficacy and …

Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing
nanotechnology to augment traditional vaccine efficacy. This review comprehensively …

Simple Summary During the last decades, scientific advances in immuno-oncology and a
better understanding of tumors' immune profile led to the development of novel …