Exactly half a century has passed since the launch of the first documented research project
(1965 Dendral) on computer‐assisted organic synthesis. Many more programs were created …

The four-membered oxetane ring has been increasingly exploited for its contrasting
behaviors: its influence on physicochemical properties as a stable motif in medicinal …

The stereoselective total synthesis of structure 1 assigned to the macrolide natural product
neaumycin B is reported in a 2.3% overall yield on 90 mg scale. The synthesis features a …

The intramolecular 1, 2-anionic migration of a silyl group from a carbon atom to an oxygen
atom was originally recognized and studied by AG Brook in the late 1950s and early 1960s …

A convergent asymmetric synthesis of the antineoplastic macrolide antibiotic cytovaricin has
been achieved through the synthesis and coupling of the illustrated spiroketal and polyol …

Marinomycins A− C (1− 3), and their monomeric analogues monomarinomycin A (m-1) and
iso-monomarinomycin A (m-2), were synthesized by a convergent strategy from key building …

The state-of-the-art in stereoselective synthesis!. Thoroughly revised and updated, this
enlarged second edition offers a plethora of valuable information on methods and reagents …

A practical stereocontrolled synthesis of (+)-discodermolide (1) has been completed in
10.3% overall yield (23 steps longest linear sequence). The absolute stereochemistry of the …

This review describes the additions of allylmagnesium reagents to carbonyl compounds and
to imines, focusing on the differences in reactivity between allylmagnesium halides and …

Discodermolide is a marine natural product reported to inhibit the proliferation of T cells and
exhibit immunosuppresive activity. Total syntheses of the natural antipode of discodermolide …