Trypanosoma evansi and Surra: A Review and Perspectives on Transmission, Epidemiology and Control, Impact, and Zoonotic Aspects
M Desquesnes, A Dargantes, DH Lai… - BioMed research …, 2013 - Wiley Online Library
This paper reviews the transmission modes of Trypanosoma evansi. Its worldwide
distribution is attributed to mechanical transmission. While the role of tabanids is clear, we …
distribution is attributed to mechanical transmission. While the role of tabanids is clear, we …
[HTML][HTML] Salivarian trypanosomosis: a review of parasites involved, their global distribution and their interaction with the innate and adaptive mammalian host immune …
M Radwanska, N Vereecke, V Deleeuw… - Frontiers in …, 2018 - frontiersin.org
Salivarian trypanosomes are single cell extracellular parasites that cause infections in a
wide range of hosts. Most pathogenic infections worldwide are caused by one of four major …
wide range of hosts. Most pathogenic infections worldwide are caused by one of four major …
Evolution of the primate trypanolytic factor APOL1
R Thomson, G Genovese, C Canon… - Proceedings of the …, 2014 - National Acad Sciences
ApolipoproteinL1 (APOL1) protects humans and some primates against several African
trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African …
trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African …
The molecular arms race between African trypanosomes and humans
E Pays, B Vanhollebeke, P Uzureau… - Nature Reviews …, 2014 - nature.com
Humans can survive bloodstream infection by African trypanosomes, owing to the activity of
serum complexes that have efficient trypanosome-killing ability. The two trypanosome …
serum complexes that have efficient trypanosome-killing ability. The two trypanosome …
[HTML][HTML] Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity
B Stijlemans, G Caljon, J Van Den Abbeele… - Frontiers in …, 2016 - frontiersin.org
The diseases caused by African trypanosomes (AT) are of both medical and veterinary
importance and have adversely influenced the economic development of sub-Saharan …
importance and have adversely influenced the economic development of sub-Saharan …
Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis
R Thomson, A Finkelstein - Proceedings of the National …, 2015 - National Acad Sciences
Apolipoprotein L-1 (APOL1), the trypanolytic factor of human serum, can lyse several African
trypanosome species including Trypanosoma brucei brucei, but not the human-infective …
trypanosome species including Trypanosoma brucei brucei, but not the human-infective …
Apolipoprotein L1 and kidney disease in African Americans
DJ Friedman, MR Pollak - Trends in Endocrinology & Metabolism, 2016 - cell.com
Genetic variants in the Apolipoprotein L1 (APOL1) gene cause high rates of kidney disease
in African Americans. These variants, found only in individuals with recent African ancestry …
in African Americans. These variants, found only in individuals with recent African ancestry …
[HTML][HTML] Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral …
S Magez, JE Pinto Torres, E Obishakin… - Frontiers in …, 2020 - frontiersin.org
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game
animals around the world. Through co-evolution with the mammalian immune system …
animals around the world. Through co-evolution with the mammalian immune system …
[HTML][HTML] The TgsGP Gene Is Essential for Resistance to Human Serum in Trypanosoma brucei gambiense
P Capewell, C Clucas, E DeJesus, R Kieft… - PLoS …, 2013 - journals.plos.org
Trypanosoma brucei gambiense causes 97% of all cases of African sleeping sickness, a
fatal disease of sub-Saharan Africa. Most species of trypanosome, such as T. b. brucei, are …
fatal disease of sub-Saharan Africa. Most species of trypanosome, such as T. b. brucei, are …
A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome
Trypanosoma brucei is the causative agent of African sleeping sickness in humans and one
of several pathogens that cause the related veterinary disease Nagana. A complex co …
of several pathogens that cause the related veterinary disease Nagana. A complex co …