Thyroid hormones are crucial for organismal development and homeostasis. In humans,
untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism …

Aberrant activation of Wnt signaling is involved in the development of several epithelial
tumors. Wnt signaling includes two major types of pathways:(i) the canonical or Wnt/β …

Organization of epithelial cells during follicular lumen formation is crucial for thyroid
morphogenesis and function of the thyroid gland; however, the molecular mechanisms …

Thyroid dysgenesis is the most common cause of congenital hypothyroidism that affects 1 in
3000 newborns. Although a number of pathogenetic mutations in thyroid developmental …

Abstract Background The transcription factor Pax8 is essential for the differentiation of
thyroid cells. However, there are few data on genes transcriptionally regulated by Pax8 other …

Abstract Papillary Thyroid Cancer (PTC) is the most common type of thyroid cancer. The
membrane-associated glycoprotein cadherin-16 (CDH16) plays a significant role in the …

Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital
hypothyroidism (CH) in both humans and mice due to decreased expression of several …

Along with insulin resistance and increased risk of type 2 diabetes (T2D), lean first-degree
relatives of T2D subjects (FDR) feature impaired adipogenesis in subcutaneous adipose …

Aim: First-degree relatives (FDR) of individuals with Type 2 diabetes (T2D) feature restricted
adipogenesis, which render them more vulnerable to T2D. Epigenetics may contribute to …

A challenging and stimulating question in biology deals with the formation of organs from
groups of undifferentiated progenitor cells. Most epithelial organs indeed derive from the …