Highlights•Dha in proteins is easily and flexibly accessible under mild conditions.•Dha
reactivity is used in β, γ-C–S/Se/N/C bond-formation and allows 'zero scar'protein …

Ubiquitination is an important protein post-translational modification regulating many cellular
processes in eukaryotes. Ubiquitination is catalyzed by a three-enzyme cascade resulting in …

Radical addition to dehydroalanine (Dha) represents an appealing, modular strategy to
access non‐canonical peptide analogues for drug discovery. Prior studies on radical …

Herein we introduce vinylphosphonothiolates as a new class of cysteine-selective
electrophiles for protein labeling and the formation of stable protein–protein conjugates. We …

Most peptide drugs contain non-proteinogenic amino acids (NPAAs), born out through
extensive structure–activity relationship (SAR) studies using solid-phase peptide synthesis …

Histone ubiquitination affects the structure and function of nucleosomes through tightly
regulated dynamic reversible processes. The efficient preparation of ubiquitinated histones …

Conspectus Protein phosphorylation is by far the most abundant and most studied post-
translational modification (PTM). For a long time, phosphate monoesters of serine (pSer) …

Ubiquitination is a versatile posttranslational modification that elicits signaling roles to
impact on various cellular processes and disease states. The versatility is a result of the …

Proteins provide an excellent means to monitor and regulate biological processes. Hence, a
precise chemical toolbox for their modification becomes indispensable. In this perspective …

Posttranslational modifications (PTMs) dramatically expand the functional diversity of the
proteome. The precise addition and removal of PTMs appears to modulate protein structure …