Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use

HC Helms, NJ Abbott, M Burek… - Journal of Cerebral …, 2016 - journals.sagepub.com
The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

KE Wang, W Chen, Z Zhang, Y Deng, JQ Lian… - Signal transduction and …, 2020 - nature.com
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no
specific and effective drugs for treating this disease have been reported until today …

CD147-spike protein interaction in COVID-19: Get the ball rolling with a novel receptor and therapeutic target

T Behl, I Kaur, L Aleya, A Sehgal, S Singh… - Science of the Total …, 2022 - Elsevier
The combat against the Corona virus disease of 2019 (COVID-19), has created a chaos
among the healthcare institutions and researchers, in turn accelerating the dire need to …

Community-acquired bacterial meningitis

D van de Beek, M Brouwer, R Hasbun… - Nature reviews Disease …, 2016 - nature.com
Meningitis is an inflammation of the meninges and subarachnoid space that can also involve
the brain cortex and parenchyma. It can be acquired spontaneously in the community …

Is COVID-19 a new hematologic disease?

B Debuc, DM Smadja - Stem cell reviews and reports, 2021 - Springer
SARS-CoV-2 viruses are positive single-stranded RNA viruses, whose infection can be
asymptomatic or lead to the coronavirus disease 2019 (Covid-19). Covid-19 is a respiratory …

Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

T Muramatsu - The journal of biochemistry, 2016 - academic.oup.com
Basigin, also called CD147 or EMMPRIN, is a transmembrane glycoprotein that belongs to
the immunoglobulin superfamily. Basigin has isoforms; the common form (basigin or basigin …

A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers

M Coureuil, H Lécuyer, S Bourdoulous… - Nature Reviews …, 2017 - nature.com
The blood–brain barrier, which is one of the tightest barriers in the body, protects the brain
from insults, such as infections. Indeed, only a few of the numerous blood-borne bacteria …

Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives

JL Berry, V Pelicic - FEMS microbiology reviews, 2015 - academic.oup.com
Prokaryotes have engineered sophisticated surface nanomachines that have allowed them
to colonize Earth and thrive even in extreme environments. Filamentous machineries …

Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection

P Fuentes-Prior - Journal of Biological Chemistry, 2021 - ASBMB
The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and
this death toll will be much higher before effective treatments and vaccines are available …