Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

B Groner, V von Manstein - Molecular and cellular endocrinology, 2017 - Elsevier
Abstract The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on
tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite …

The multifaceted role of STAT3 in NK-cell tumor surveillance

A Witalisz-Siepracka, K Klein, B Zdársky… - Frontiers in …, 2022 - frontiersin.org
Signal transducer and activator of transcription 3 (STAT3) is a member of the Janus kinase
(JAK)-STAT pathway, which is one of the key pathways contributing to cancer. STAT3 …

Expression of immune related genes and possible regulatory mechanisms in Alzheimer's disease

Y Lu, K Li, Y Hu, X Wang - Frontiers in immunology, 2021 - frontiersin.org
Immune infiltration of peripheral natural killer (NK) cells in the brain has been observed in
Alzheimer's disease (AD). Immunity-related genes (IRGs) play an essential role in immune …

STAT5 is a key regulator in NK cells and acts as a molecular switch from tumor surveillance to tumor promotion

D Gotthardt, EM Putz, E Grundschober… - Cancer Discovery, 2016 - AACR
Natural killer (NK) cells are tightly regulated by the JAK–STAT signaling pathway and cannot
survive in the absence of STAT5. We now report that STAT5-deficient NK cells can be …

Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance

D Gotthardt, EM Putz, E Straka… - Blood, The Journal …, 2014 - ashpublications.org
The members of the signal transducer and activator of transcription (STAT) family of
transcription factors modulate the development and function of natural killer (NK) cells. NK …

Regulation of natural killer cell function by STAT3

NA Cacalano - Frontiers in immunology, 2016 - frontiersin.org
Natural killer (NK) cells, key members of a distinct hematopoietic lineage, innate lymphoid
cells, are not only critical effectors that mediate cytotoxicity toward tumor and virally infected …

STAT3 inactivation suppresses stemness properties in gastric cancer stem cells and promotes Th17 in Treg/Th17 balance

M Hajimoradi, A Rezalotfi… - International …, 2022 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) has been recognized with dual
effects in provision of cancer; either tumor inductive or immune suppressive. Recent findings …

STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance

A Witalisz-Siepracka, CM Denk, B Zdársky… - Frontiers in …, 2024 - frontiersin.org
Acute myeloid leukemia (AML) is a heterogenous disease characterized by the clonal
expansion of myeloid progenitor cells. Despite recent advancements in the treatment of …

Suppressor of cytokine signaling 2 negatively regulates NK cell differentiation by inhibiting JAK2 activity

WS Kim, MJ Kim, DO Kim, JE Byun, H Huy, HY Song… - Scientific Reports, 2017 - nature.com
Suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine
responses. Although recent reports have shown regulatory roles for SOCS proteins in innate …

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice

P Pathria, D Gotthardt, M Prchal-Murphy… - …, 2015 - Taylor & Francis
Myeloid cells lacking STAT3 promote antitumor responses of NK and T cells but it is
unknown if this crosstalk affects development of autochthonous tumors. We deleted STAT3 …