Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …

Clostridium difficile is the main causative agent of antibiotic-associated and health care-
associated infective diarrhea. Recently, there has been growing interest in alternative …

Abstract Background Clostridioides (Clostridium) difficile is an important pathogen of
healthcare-associated diarrhea, however, an increase in the occurrence of C. difficile …

Background It has been thought that Clostridium difficile infection is transmitted
predominantly within health care settings. However, endemic spread has hampered …

Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-
associated diarrhea in humans, presenting a significant burden to global health care …

Multi-locus sequence typing (MLST) is a high-resolution genetic typing approach to identify
species and strains of pathogens impacting human health, agriculture (animals and plants) …

Metronidazole was until recently used as a first-line treatment for potentially life-threatening
Clostridioides difficile (CD) infection. Although cases of metronidazole resistance have been …

Antibiotic-resistant Clostridioides difficile is an anaerobic Gram-positive bacterium that
colonizes the colon and is responsible for more than 29,000 deaths in the United States …

The symptoms of Clostridium difficile infection are caused by toxins expressed from its 19 kb
pathogenicity locus (PaLoc). Stable integration of the PaLoc is suggested by its single …

Gastrointestinal infections often induce epithelial damage that must be repaired for optimal
gut function. While intestinal stem cells are critical for this regeneration process [RC van der …