Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Obstructive sleep apnea in cardiovascular disease: a review of the literature and proposed multidisciplinary clinical management strategy

JR Tietjens, D Claman, EJ Kezirian… - Journal of the …, 2019 - Am Heart Assoc
Cardiovascular disease (CVD) remains a highly prevalent cause of morbidity and mortality,
both in the United States and worldwide. In parallel with the development of new and …

Obstructive sleep apnea: current perspectives

AM Osman, SG Carter, JC Carberry… - Nature and science of …, 2018 - Taylor & Francis
The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Adult obstructive sleep apnoea

AS Jordan, DG McSharry, A Malhotra - The Lancet, 2014 - thelancet.com
Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway
collapse during sleep, leading to oxygen desaturation and disrupted sleep. Features include …

Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets

DJ Eckert, DP White, AS Jordan, A Malhotra… - American journal of …, 2013 - atsjournals.org
Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …

Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

Bi-directional relationships between co-morbid insomnia and sleep apnea (COMISA)

A Sweetman, L Lack, RD McEvoy, S Smith… - Sleep medicine …, 2021 - Elsevier
Insomnia and obstructive sleep apnea (OSA) commonly co-occur. Approximately 30–50% of
patients with OSA report clinically significant insomnia symptoms, and 30–40% of patients …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches

AV Zinchuk, MJ Gentry, J Concato, HK Yaggi - Sleep medicine reviews, 2017 - Elsevier
Obstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea
hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced …