Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Radiotherapy should have low toxicity in the entrance channel (normal tissue) and be very
effective in cell killing in the target region (tumour). In this regard, ions heavier than protons …

Background and purpose The FLASH effect is a potential breakthrough in radiotherapy
because ultra-high dose-rate irradiation can substantially widen the therapeutic window …

Cancer therapy with accelerated charged particles is one of the most valuable biomedical
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …

Purpose To establish a beam monitoring and dosimetry system to enable the FLASH dose
rate carbon ion irradiation and investigate, at different oxygen concentrations, the in vitro …

Compared with conventional radiotherapy, ultrahigh dose-rate (FLASH) radiotherapy spares
normal tissues through oxygen exhaustion. However, residual cancer stem cells (CSCs) …

While FLASH radiation therapy is inspiring enthusiasm to transform the field, it is neither new
nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials …

Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical
use of RT requires a balance to be struck between tumor effect and the risk of toxicity …

Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …