The Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is responsible for the
activating phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell …

Cell division in eukaryotes is a highly regulated process that is critical to the life of a cell.
Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase …

The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors in EGFR-
mutant non-small-cell lung cancer (NSCLC) is limited by the development of drug-resistance …

PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4)(IC50, 0.011
μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional …

Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for
cancer progression. We report here a novel subseries of C-5-substituted anilinoquinazolines …

The HYDE scoring function consistently describes hydrogen bonding, the hydrophobic effect
and desolvation. It relies on HYdration and DEsolvation terms which are calibrated using …

CDK7, a member of the cyclin-dependent protein kinase family, regulates the activities of
other CDKs through phosphorylation on their activation segment and hence contributes to …

Cyclin-dependent kinases (Cdk) and their associated pathways represent some of the most
attractive targets for the development of anticancer therapeutics. Based on antitumor activity …

The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective
inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are …

Cell-permeable small molecules that inhibit their targets on fast timescales are powerful
probes of cell-division mechanisms. Such inhibitors have been identified using phenotype …